Top 10 Best Kratom Potentiators (How to Potentiate Kratom by 200%)

If you are looking for the best kratom potentiators that work, you will soon be pleased.

The best enhancer on how to potentiate kratom can:

  • Improve the duration of kratom
  • Bring out all the benefits of kratom
  • Lower your need for kratom consumption for analgesic effects to kick in
  • “Fix” your kratom tolerance

(1) GABA Brain Food (Only for Intense Relaxation)

kratom potentiators

This supplement is designed to enhance and maintain healthy brain function. I noticed it worked well with kratom.

If you are looking for how to potentiate kratom that will put you to sleep in no time, look no further.

To understand how you can use this to spark up kratom I’ll explain how it works.

GABA (Gamma-Aminobutyric Acid) is naturally produced by your body.  It is a neurotransmitter, a brain chemical crucial for mental calm. It slows down brain activity so you can have more fluid thoughts and relax.

Brain Food Is Loaded With 3 Kratom Potentiators

This supplement is also infused with three ingredients:

  • L-Citrulline
  • Rosmarinic acid
  • Grape seed extract

a. L-Citrulline

This amino acid is found in foods like watermelon, beef, and pork. L-Citrulline helps transport GABA to your brain.

Kratom itself acts on GABA receptors in your brain so this supplement alone is effective.

b. Rosmarinic Acid

Found in natural herbs like rosemary. It slows down the breakdown of GABA, which makes the calming effects of kratom last longer. Rosmarinic Acid alone promotes relaxation.

c. Grape Seed Extract

Works similarly to L-Citrulline. Grape seed extract helps GABA to cross the blood-brain barrier and transport it further to your brain.

Try GABA Brainfood

Why Brain Food Is Loved by Many Kratom Users

Take this supplement if you want to potentiate kratom and its relaxing effects. You’ll feel a sense of serenity. At night you can drift into a deep and rejuvenating sleep.

Kratom itself acts on the neurotransmitter GABA. This supplement will work together with kratom to produce stronger and unique experiences. A true potentiator that enhances all aspects of the effects of kratom.

Probably the only one you’ll notice a difference. Good if you have brain fog.

Top 9 Standalone Kratom Potentiators I Use

I will explain the best kratom potentiators and how you should use them for maximum benefits. These are scientifically proven to work in synergy with kratom alkaloids.

(2) Agmatine

Agmatine is a metabolite of an essential amino acid called L-arginine. It works in synergy with opioids to relieve pain. It reduces NITRIC oxide production. This will then reduce inflammation in your body, and in the end, less pain for you.

How Agmatine Potentiates Kratom Powder

By inhibiting the production of nitric oxide, agmatine helps reduce inflammation in the body, which in turn helps to reduce pain.

Agmatine Lowers Tolerance

Agmatine can also reduce opioid tolerance. This allows you to take a lower dose but still get the same pain relief as you would at higher doses. It works by blocking receptors that opioid substances bind to.

Agmatine can release some opioids by stimulating the adrenal glands. The release of β-endorphin is released, which is a naturally produced opioidergic painkiller.

You should try agmatine if you want to enhance the experience and only use kratom for pain relief.

(3) Akuamma Seed

Akuamma tree has a lot in common with kratom. Both come from tropical trees, have a bitter taste, and are structurally related.

Kratom alkaloids and akuamma will produce longer-lasting effects. Akuamma has an alkaloid called “akuammine”. It is structurally similar to mitragynine, the main alkaloid in kratom.

Akuamma Potentiates Kratom By Stimulating Same Brain Receptors

These 2 share many benefits that will give you longer Kratom experiences. This is possible because akuamma binds to the same opioid receptors

Some people who have tried it say it’s the best kratom potentiator while others can’t stand the taste.

(4) Grapefruit Juice


This article won’t be complete if I didn’t include grapefruit. Why? Grapefruit stimulates the metabolism of kratom. More active alkaloids in your system are now stronger and stay in your system longer.

Why Grapefruit Is a Must-Have Kratom Potentiator

Grapefruit blocks enzymes that break down the alkaloids in kratom. This makes the alkaloids more efficient and they can do more work. You will have a longer kratom experience as well. You can expect the effects of kratom to last for 10 hours.

It will also enhance the duration of effects. I notice the energizing effects with certain strains work on a daily basis. The stimulating effects from white maeng da and grapefruit juice seem to only bring out positive effects.

I use grapefruit to potentiate the kratom experience. Both taste and potency are enhanced. What else can I ask for? You can use one fruit and blend it using a mixer. When you finish let it sit for 10 minutes so the juice has time to do the work on the plant.

(5) Turmeric


Turmeric, which is a polyphenol with extensive health benefits, is a reliable kratom potentiator that can enhance the effects and make them last longer.

It helps your system to make use of kratom alkaloids efficiently. Turmeric slows down metabolism and reduces side effects like nausea that Kratom can cause.

How to Potentiate Kratom With Turmeric

Turmeric has curcumin, an anti-inflammatory antioxidant. It binds to kratom alkaloids and increases plant absorption.

It works perfectly even if you’ve developed a tolerance to kratom. I suggest using premade turmeric shots or a potent extract.

Besides strengthening kratom, turmeric can also decrease inflammation and general pain, which makes it an excellent source of additional pain management to add to the mix.

(6) DLPA

DLPA is an amino acid used for pain relief and to improve mood. Combining it with kratom will enhance the pain relief it offers.

The potential benefits are more than pain.

DLPA can also increase your energy and concentration abilities. A good choice if you want a kratom potentiator that will boost your energy levels. Some people also get mild euphoric effects from DLPA alone. If you are after the euphoria, you need high kratom doses and the right kratom strains.

How DLPA Potentiates Kratom

DLPA increases dopamine and norepinephrine levels in your brain. Two neurotransmitters that regulate pain, mood, energy, and concentration.

These brain chemicals are pivotal for pain and mood.

When you increase dopamine and norepinephrine, DLPA can enhance the kratom alkaloids and give you stronger and longer pain relief experiences.

DLPA gives you more motivation and a sense of well-being.

This is a great kratom potentiator to boost your mood.

(7) Cayenne Pepper

Found in many spicy meals, cayenne pepper can enhance your kratom experience. You must be mindful of doses because they can build up a tolerance.

Cayenne pepper and grapefruit juice are popular potentiators because they work with all forms of kratom. 

How Cayenne Pepper Potentiates Kratom

Cayenne contains capsaicin. It increases the absorption rate of kratom alkaloids.

Capsaicin allows kratom to be quickly absorbed into your bloodstream. This makes you experience kratom for a longer time than if you did not take this kratom potentiator.

Cayenne pepper is also known for its analgesic properties.

Mix the pepper and kratom with water and feel the difference. Some people take turmeric also to spice up the mix, but if it’s your first time potentiating kratom try one at a time.

Spicy food and snacks seem to work well as kratom potentiators.

(8) Cat’s Claw

Cat’s claw is an herb that is known for its immune-boosting and anti-inflammatory properties. It can also enhance the effects of Kratom by increasing the absorption of Kratom alkaloids.

To use cat’s claw as a Kratom potentiator, simply take it as a supplement before consuming Kratom.

How Cat’s Claw Potentiates Kratom

The alkaloids in cat’s claw improve kratom absorption in the liver and increase bioavailability. This gives you stronger effects that last longer because kratom remains in your bloodstream for longer.

(9) Lemon Balm

lemon balm

A popular mild sedating herb, Lemon Balm works well to calm down brain activity so it is easier to drift into a restful sleep. It is a gaming herb with sedative effects because of high levels of terpenes.

How Lemon Balm Potentiates Kratom

It works well on its own but with kratom, the sedating effects are enhanced.

The potency of kratom is not the only thing enhanced. Just like lemon juice, this one will improve the taste of kratom.

To understand how it can improve the strength of kratom and lower tolerance levels, you can look at the scientific evidence of terpenes.

Terpenes work on the limbic system. The part of the brain that handles emotions and is pivotal to your sleep quality.

Lemon balm reduces stress and anxiety so you can sleep better at night. It also increases GABA chemicals in your brain. This will reduce brain activity and enhance relaxation.

Lemon balm can increase the absorption of kratom alkaloids to make the sedative effects stronger.

(10) CBD

CBD oil

CBD is the non-psychoactive ingredient in the cannabis plant. Kratom and CBD from cannabis are both god-sent herbs that you can use for many health benefits. Pain management, fibromyalgia, depression, and anxiety to name a few.

How CBD Potentiates Kratom

CBD does its magic to stimulate and balance your endocannabinoid system, which regulates physiological and cognitive processes, including pain and mood.

You using CBD to potentiate kratom is something you won’t regret anytime soon. Just like kratom, CBD is booming online.

CBD is good for pain and it deserves everyone’s attention if they are using kratom for dealing with pain.

2 Enzymes that Are Best Kratom Potentiators to Enhance Bioavailability

digestive system

Digestion is basically the process of breaking down food into smaller molecules that your body can use. When you take kratom your body won’t necessarily utilize it 100% if your digestive system isn’t operating efficiently.

You can improve your digestion with two supplements:


Pancreatin is a supplement mixture of enzymes used to break down food. This supplement is recommended to treat problems with the digestive system and malabsorption.

Papaya Enzymes

This tasty fruit is filled with enzymes to help digestion and stabilize blood sugar levels. Papaya enzymes are an excellent source of enzymes to take with food because some enzymes diminish during cooking.


There are a wide variety of choices on how to potentiate kratom. From your favorite juice to a spicy pepper.

Ever since kratom became available online people have tried and experimented to enhance its power. These are my favorite kratom potentiators that work well. Grapefruit and turmeric are my absolute favorite.

Try different ones from this list and you’ll eventually find the one your body likes. Some kratom potentiators, such as cayenne pepper, turmeric, and grapefruit seem to work for most people. 

If you want to boost kratom’s pain relief you should try agmatine.

How do you potentiate your kratom? Add a comment and teach me.


Agmatine – Scientific Review

Cannabinoids in the management of difficult to treat pain

  • Gary Maccartney says:

    Where can I purchase this product

  • DlLPA is an amazing kratom potentiator! Its boosts its pain killing and mood boosting effects.

    • I was wondering if they worked well together. Does dpla help kratom work better?

    • Adrian XH says:

      I tried it and yes, it is amazing. Just added it to the list.

  • Is there a suggested amount of tumeric an cayenne?

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