Sunifiram, an AMPAkine nootropic derived from Piracetam with positive results to enhance memory and focus. People who tried it say it feels like a stimulant. Many find it useful for concentration and to stop procrastinate in school and work. Users have also reported increased perception and clear thinking.
This article takes the mystery out of if you should add this noot to your nootropic stack or not. You’ll read real life Sunifiram experiences, the benefits, side effects, and proper dosage.
Sunifiram (DM-235) is a young nootropic developed as a research chemical. It is structurally related to Piracetam, Sapunifiram, and Unifiram. Some people think it’s a racetam, it works similarly, but it’s not put it that category.
Speaking of Piracetam, Sunifiram is stronger regarding potency and anti-amnesiac qualities.
Sunifiram can enhance memory retention and learning abilities. The speed of recall and information processing.
Many users also report improved motivation and perception. Colors and sounds appear more vivid and more distinctive. Music sounds better, emotionally, when listening with headphones. The increased perceptual awareness can make you pay attention to details with excitement and more depth.
I’m sold. Sunifiram looks like a good nootropic for productivity for all kinds of work. Making music, writing, or learning new things.
Some say sunifiram is even stronger than noopept. But it’s important to know that both works differently.
Noopept binds to glutamate receptors, and stimulate neurotrophic factors—your brain’s ability to form and maintain mature and developing neurons. Sunifiram works on glutamatergic AMPA receptors and stimulates the growth of synapses.
It’s not fully understood how sunifiram works, yet. But right now we know that the primary action is that of an ampakine, which means it stimulates glutamate. And it may also release acetylcholine.
Interesting things starts to happen after it penetrates the blood-brain barrier.
Sunifiram stimulates the growth of synapses and improves neuron communication. Similar to nefiracetam, sunifiram works on glycine binding site on NDMA receptors.
Sunifiram can also enhance long-term potentiation. LTP handles signal transmission between two neurons. And it’s one of the major mechanism that underlies memory and learning.
Enhanced acetylcholine in the prefrontal cortex leads to improved thinking and alertness—since acetylcholine enhances the communication to the right and left brain hemisphere. It is also important for memory and attention.
What’s so Special about Glutamate?
The most abundant neurotransmitter in the vertebrate nervous system is glutamate. This neurotransmitter is used by major information pathways in the brain—accounting over 90% of the synaptic connections. It’s also important for memory formation, learning, regulation, and neural communication.
AMPA is a part of the glutamate system that mediates fast synaptic transmission in the central nervous system.
Keep in mind that every individual will have different experiences because everyone has unique brain chemistry, lifestyle, and diet. Before you experiment with this substance, you can expect some things to happen. And what’s better than reading real life experiences?
“I started five days ago with 10mg of Sunifiram administered sublingually. Approximately 10-15 minutes after the first dose I felt what others have called “sunny.” It is hard to explain but it was somewhat overwhelming, and the effect did not last long. The following day I took the same dose and got the same but short effect. I did have a mild headache after waking up but nothing unbearable. I started to get the full effect on Day 3. Suddenly I was able to focus on whatever I wanted, and the ideas flowed easily. I had struggled to finish a paper for days, but this time I finished it in less than an hour. Today is Day 5 of using Sunifiram, and I have to say it has been a positive experience so far.
As far as effects, I would say the average time it takes to kick in is about the same as noopept… say 10-15 minutes. After the initial waiting period for the effects, I felt a slight change in perception and attention. I got that similar “enhanced” effect I feel from noopept, with a bit more of a rushing onset. Whereas noopept provides a gradual increase, I feel like sunifiram have a very quick onset of full effect. I was switching attention between an episode of Archer, and a conversation with my fiancé and I felt like I was able to totally change my direction of thinking and experience whichever I was focusing on with full focus. There was a slight euphoria along with all of this as well…
It’s not easy to pinpoint the universal dosage. But 1mg/kg has shown to be enough for mice and rats. And that can be translated to 0.08-0.16mg/kg for a 150lb person.
In short: 5.4-11mg.
A 10mg dose is safe. A user who tried it in this stage report increased body temperature and stimulant effects like Adderall.
However, for beginners, 3mg is the minimal starting point. Increase if needed.
Sunifiram has no records of serious side effects or toxicity. It’s probably best to avoid regular use if you’re concerned about your health since it’s an understudied nootropic.
The common side effects are:
Sunifiram performs well in nootropic stacks. Alpha GPC should be there since it will make sure your choline levels are flowing so you stay out of headaches. Strong nootropics tend to deplete choline levels. CDP-choline and centrophenoxine can also do the job. Some people like to throw in sulbutiamine and aniracetam for even stronger increased motivation and drive. But don’t ignore a good choline source.
Sunifiram sounds like a decent noot. It’s not fully understood, far from it. But from what the studies say, it’s safe to say that it’s an excellent memory and focus enhancer.
Because of the limited research, you should approach it with caution and avoid long-term use.
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