Sulbutiamine: Supercharge Thiamine to Reap These Benefits

By Nootroholic | Achievement & Mindset

sulbutiamine review

Sulbutiamine was made for one reason: to reverse chronic thiamine deficiency. If you drink alcohol or have in the past, then it can do wonders for your brain.

And that should be your main reason to buy.

Thiamine deficiency is also common among people who eat white rice and flour, or highly refined carbohydrates.

For healthy brains, there’s evidence that it can improve:

  • Memory
  • Eyesight
  • Planning skills
  • Erectile dysfunction

Editor’s Note:

Sulbutiamine has been my top favorite nootropics for a while now. I take 600mg every day because it has enhanced my mental clarity like nothing else. Must be because of the thiamine boost that alcohol had squeezed out from me. It’s amazing to see the goods that come out when you boost thiamine. Imagine what happens if you also balance the other ”brain chemicals”.

Sulbutiamine and Alcohol

Why is it important to take sulbutiamine if you drink alcohol?

There’s a strong link between frequent alcohol consumption and diminished brain function. It depletes glucose, the brain’s main source of energy, and shatters your ability to convert short-term memories into long-term.

More importantly, alcohol burns thiamine and hurts the connection between brain cells. When thiamine is low, cerebral blood flow, peripheral nerves, thalamus, and the cerebellum is worsened.

Only moderate alcohol is good for the brain.

Red wine, for example, has shown to fight Alzheimer’s by removing protein plaques. Champagne is high on polyphenols, a strong antioxidant that combat certain effects of aging, like dementia.

But Here We Care About Our Brains More Than Usual

And we want all the brain chemicals, in this case, thiamine, to flow in abundance. Because it is critical for glucose to convert to energy in the brain. Acetylcholine, the ”memory and learning neurotransmitter”, depends on it.

When acetylcholine is low, people miss appointments, misplace keys, forget birthdays, and learning becomes harder than necessary.

That’s a reason THC in Marijuana makes people forgetful. Alpha GPC would be a good pick in this case if you want choline directly transported to your brain.

Now you might wonder:

What is Sulbutiamine?

Sulbutiamine (brand name: Aracalion) is an enhanced form of thiamine designed to reverse thiamine deficiency.  Too low levels can cause severe mental confusion and depression.

Thiamine alone can improve cognitive function. But it has low absorption rate. Not enough enters your brain for you to get the nootropic benefits.

Sulbutiamine has two thiamine molecules bound together by a sulfur group. Now it can cross the blood-brain barrier and improve your brain without effort.

Benefits of Sulbutiamine

There is more evidence to support these claims, but a lot haven’t been translated into English.


Sulbutiamine has shown to improve long-term memory formation and deny the effects of memory loss (Alzheimer’s) after consistent use. [1] [2]

It’s a key ingredient in my best nootropic stack for memory.

Decision Making

Sulbutiamine stimulate brain regions that organize decision and strategies. [3]

I use 600mg every day and I can feel it’s true.

Psychogenic Erectile Dysfunction

Sulbutiamine can normalize cavernous electric activity in 8 patients with arterial disorders. [4]

This means that sulbutiamine is an effective tool for psychogenic erectile dysfunction. Young men who watch porn in early age and continue for years are at high risk to develop ”porn-induced erectile dysfunction”.


First of all, people with glaucoma have low thiamine. And secondly, sulbutiamine interacts with retinal cells and reduce cell death in serum-deprived cells. [5] [6] [7]

Focus & Energy

Sulbutiamine can enhance focus, increase energy levels, and reduce, or eliminate chronic fatigue.

Sulbutiamine and noopept work well together. Both stimulates glutamate and glucose.


Sulbutiamine affects dopamine, which is why you get more focus and personal drive. But works much better in a stack for motivation than alone.

Sulbutiamine Uses

Besides improving memory and treating alcoholism, sulbutiamine is also used for:


The lowest sulbutiamine dose is 200mg. According to human studies, 400mg daily have shown great results. But you can take up to 800mg per day, preferably with a good fat source like fish oil, or better yet, Avocado.

If you want better memory, you should supplement at least 400mg every day without cycling.

Side Effects

I’ve used it every day for months. Nothing negative has happened. But this doesn’t mean everyone will have the same experience. The common side effects include anxiety and irritation. Only a few reports on nausea.

The source is a big cofactor if you’ll experience anything, benefits or side effects.

Last Thoughts

Sulbutiamine is extra powerful compared to original thiamine.

It was designed to reverse depleted thiamine in the brain.

But it’s also useful for healthy individuals looking for cognitive enhancements.

You should use it if you have a history of alcohol use or eat a lot of refined carbohydrates.

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