SLU-PP-332, also written SLU PP 332, is a lab-made exercise mimetic that made untrained mice run about 70% longer. No human trial exists, and it is not FDA-approved.
It switches on ERR receptors in muscle, the same pathway endurance training activates, and it almost stopped fat gain in obese mice. It is sold for research use only. Evidence grade: animal only, as of October 24, 2026.
If you are weighing capsules, read this first: the lab that invented SLU-PP-332 wrote in 2025 that it lacks oral bioavailability. Vendors sell it as capsules anyway.
The capsule we checked
Swiss Chems SLU-PP-332 capsules
100 mg per capsule · 60 capsules · Research use only
100.01 mgmeasured per capsule against a 100 mg label. LC-MS confirms the compound is SLU-PP-332 (Freedom Diagnostics, reported September 24, 2026).
$196.95for 60 capsules, as of October 24, 2026
LimitThe report prints no purity percentage, and no study shows that capsules deliver SLU-PP-332 into the blood.
30-day returns on unopened bottles. Same-day US dispatch on orders before 12 PM EST.
What is SLU-PP-332?
SLU-PP-332 is a synthetic small molecule built at Saint Louis University, which is where the “SLU” comes from. It activates three receptors called ERRα, ERRβ and ERRγ. These receptors help muscle cells build mitochondria and burn fat, and endurance exercise switches on the same pathway (ACS Chemical Biology, 2023).
It is not a peptide. It has no peptide bond, even though most peptide vendors list it.
How to read it. Blue: a fact about the molecule. Amber: animal or unproven. Red: no human data or not allowed.
| Fact | Status | Detail |
|---|---|---|
| Type | Small molecule | C18H14N2O2, CAS 303760-60-3. Not a peptide. Activates ERRα, ERRβ and ERRγ, strongest at ERRα. |
| Human trials | None | ClinicalTrials.gov lists 0 studies (October 24, 2026). No human study is published. |
| Animal data | Mice | Endurance, fat-gain and heart-failure studies, published 2023 to 2025 by Saint Louis University and partner labs. |
| FDA status | Not approved | Sold as a research chemical, not for human consumption. |
| Capsules | Unproven | The inventors describe SLU-PP-332 as lacking oral bioavailability. |
| Sport | Treat as banned | WADA prohibits metabolic modulators. Its 2027 list names SLU-PP-332, per a law-firm briefing. |
How does SLU-PP-332 work?
SLU-PP-332 binds three estrogen-related receptors, ERRα, ERRβ and ERRγ, and switches them on. It is strongest at ERRα, and the endurance gain in mice depended on ERRα (ACS Chemical Biology, 2023).
- It starts an exercise gene program. In mouse muscle it switched on genes that a single bout of aerobic exercise switches on, such as Ddit4.
- It shifts muscle fibers. Mice developed more type IIa oxidative fibers, the kind built for endurance.
- It raises mitochondrial function. Muscle cells in a dish increased cellular respiration.
- It acts through ERRγ in the heart. In heart-failure mice, ERRγ drove the protective effect.
None of this has been measured in human muscle.
Does SLU-PP-332 work? Benefits shown in mice
In mice, yes. In people, no one has tested it. Each result below carries its evidence grade.
- Endurance (animal): Mice given SLU-PP-332 ran about 70% longer and 45% farther than untreated mice, without training. ACS Chemical Biology, 2023
- Fat gain (animal): Obese mice on a high-fat diet weighed about 12% less after 28 days. They gained under 0.5 g of fat, against about 5 g in untreated mice. Food intake did not change. J Pharmacol Exp Ther, 2024
- Heart failure (animal): In mice with pressure-induced heart failure, it improved ejection fraction, reduced fibrosis and raised survival. Circulation, 2023
- People (none): No published human study and no registered trial as of October 24, 2026.
Mouse results often fail in people, so a 12% weight drop in obese mice does not forecast yours.
The mechanism sets it apart from GLP-1 drugs such as retatrutide, which cut appetite. SLU-PP-332 left food intake unchanged in mice. The weight difference came from burning more fuel.
Does SLU-PP-332 work orally? Why capsules are unproven
Capsules are unproven, and the inventors flag the reason. In a 2025 paper, the lab describes SLU-PP-332 as lacking oral bioavailability. The same paper introduces SLU-PP-915, a different molecule that is orally active in mice (J Pharmacol Exp Ther, 2025).
The endurance and fat studies gave SLU-PP-332 by injection, twice a day. No study has measured how much of a capsule reaches human blood. Read every capsule listing, including the one reviewed below, with that gap in mind. For the general problem, see can you take peptides orally.
SLU-PP-332 side effects
No human safety data exists. The record is mouse data and anecdotes.
- Mice (animal): Liver enzymes did not rise in the 28-day obesity study. In one mouse model, the treatment arm was cut to 12 days because the mice tolerated twice-daily injections poorly.
- User reports (anecdote): Forum posts and vendor pages mention warmth or sweating, poor sleep when taken late in the day and a faster resting heart rate. None of it comes from a controlled study.
- Long term (unknown): The mouse studies ran from days to weeks. No long-term safety study exists in any species.
Can SLU-PP-332 cause cancer?
No cancer-safety study of SLU-PP-332 has been published. ERRα is highly expressed in some breast cancers, and higher levels track with worse outcomes in triple-negative disease (review, 2023). Switching ERRα on raises an untested question: a theoretical concern, not a finding. If you have had cancer, talk to your oncologist before considering any ERR agonist.
Does SLU-PP-332 suppress appetite?
Not in mice. Food intake stayed the same. There is no human data.
SLU-PP-332 reviews: what users report
There are no clinical reviews of SLU-PP-332, because there are no clinical trials. What exists is self-reported. It comes from forums and vendor-affiliated pages, which skew positive.
- Energy and stamina (anecdote): Some users describe a burst of energy and more stamina.
- Body (anecdote): Sweating, a warm feeling and a faster resting heart rate.
- Sleep (anecdote): Trouble falling asleep when taken late in the day.
Self-reports cannot separate a compound from placebo, expectation or training. Treat them as leads, not proof.
SLU-PP-332 dosage: why there is no human dose
There is no human dose, because there is no human trial. We do not publish dose numbers, schedules or cycles for it.
Published daily amounts span a 1,000-fold range. They come from scaling mouse studies or from vial sizes, not from human data.
A number with no trial behind it is a guess. The mouse papers linked above list the methods used in animals. For human use, ask a physician who knows your health history.
Is SLU-PP-332 legal? Can athletes use it?
- United States: Not FDA-approved for any use. Vendors sell it as a research chemical labeled not for human consumption. Status as of October 24, 2026.
- Sport: WADA bans metabolic modulators. Its 2027 list, approved on September 10, 2026, names SLU-PP-332 and SLU-PP-915 as examples, effective January 1, 2027, according to a law-firm briefing. Anti-doping labs have already published how its metabolites can be detected (2026 study). If you are tested, treat it as prohibited.
Who should not use SLU-PP-332
- Anyone under 18.
- Tested athletes (WADA, NCAA).
- Pregnant or breastfeeding women.
- Anyone with a cancer history, unless an oncologist agrees.
How to check a SLU-PP-332 lab report before you buy
Read the lab report before the price. A usable report has five things:
- A lot number that matches the label on your product.
- Identity by mass spectrometry (LC-MS) showing SLU-PP-332, mass about 290 g/mol.
- A purity percentage from HPLC. “Confirmed” alone is not a purity result.
- Net content that matches the label claim.
- A named lab, a report date and a way to look the report up.
Etsy and eBay listings carry no verifiable lab report, so skip them. For the full method, read how to verify a peptide COA and peptide scams to avoid. SLU-PP-332 is not a peptide, but the report-reading steps are the same.
SLU-PP-332 capsules: the lab report we checked
Swiss Chems sells SLU-PP-332 as 100 mg capsules, 60 per bottle, for $196.95 (as of October 24, 2026). The listing is marked research use only.
What the lot 3583 report shows:
- Lab: Freedom Diagnostics Testing. Sample received September 23, 2026, reported September 24, 2026.
- Identity confirmed as SLU-PP-332 by LC-MS.
- Net content of 100.01 mg per capsule, against a 100 mg label.
What it does not show:
- A purity percentage. The product page advertises 99% purity, and the report prints no purity figure.
- Sterility, endotoxin or heavy-metal results.
- Absorption. A capsule can match its label and still deliver little (see above).
- Your lot. The report covers lot 3583. Ask for your bottle’s lot number before you order.
SLU-PP-332 vs retatrutide, tesofensine and other fat-loss compounds
Evidence separates these compounds more than mechanism does.
How to read it. Green: human trials exist. Amber: limited human data. Red: no human data.
| Compound | Human evidence | How it acts |
|---|---|---|
| 1SLU-PP-332This page | No human dataMice only | Activates ERR receptors and burns more fuel. Food intake stayed flat in mice. |
| 2RetatrutideGIP, GLP-1 and glucagon agonistRead the guide → | Phase 3Not approved (October 2026) | Cuts appetite. |
| 3TesofensineMonoamine reuptake inhibitorRead the guide → | Human trialsNot FDA-approved | Raises brain monoamines and cuts appetite. |
| 45-Amino-1MQNNMT inhibitorRead the guide → | No human dataAnimal data | Blocks NNMT and raises NAD+. |
| 5MOTS-cMitochondrial peptideRead the guide → | LimitedFew small studies | Activates AMPK in cells. |
No human study has tested SLU-PP-332 with retatrutide or BAM15, and we do not cover combinations.
What we know, what we don’t, what would change our mind
- Known (animal): In mice it raised endurance, limited fat gain and improved heart function in heart failure, while food intake stayed flat.
- Unknown: Whether it does anything in people, what human exposure is safe, whether capsules absorb, and long-term and cancer safety.
- Would change our mind: A published human safety and pharmacokinetic study, oral absorption data for SLU-PP-332 itself, and replication by labs outside the group that invented it. The three mouse papers above share authors.
SLU-PP-332 FAQ
Is SLU-PP-332 a peptide?
No. It is a synthetic small molecule (C18H14N2O2, CAS 303760-60-3) that activates ERR receptors. It has no peptide bond. Many peptide vendors list it anyway.
What does SLU-PP-332 do?
In mice it raised running endurance by about 70%, cut fat gain on a high-fat diet and improved heart function in heart failure, without changing food intake. Evidence grade: animal only.
Does SLU-PP-332 work in humans?
No human data exists. No human study has been published, and ClinicalTrials.gov listed no trials on October 24, 2026.
Does SLU-PP-332 work orally?
Oral use is unproven. A 2025 paper from the lab that developed it describes SLU-PP-332 as lacking oral bioavailability, and no study has measured capsule absorption in people.
Is SLU-PP-332 safe?
Human safety is unknown. No human safety study exists. In mice, liver enzymes did not rise over 28 days, and no long-term study exists in any species.
Does SLU-PP-332 help you lose weight?
In obese mice it cut weight gain: about 12% less body weight after 28 days on a high-fat diet. No human weight-loss data exists.
Does SLU-PP-332 build muscle?
No evidence shows it builds muscle size. In mice it increased oxidative type IIa fibers, which support endurance, not bulk.
Does SLU-PP-332 raise heart rate or blood pressure?
No study has measured either in humans. User reports mention a faster resting heart rate. In mice with heart failure, heart function improved.
How long does SLU-PP-332 take to work?
No human timeline exists. In mice, the endurance test followed about a week of treatment, and the fat study ran 28 days.
Does SLU-PP-332 suppress appetite?
Not in mice. Food intake stayed the same while fat gain dropped. There is no human data.
Does SLU-PP-332 cause cancer?
No cancer-safety study of SLU-PP-332 has been published. ERRα is highly expressed in some breast cancers, so switching it on is a theoretical concern, not a finding. Anyone with a cancer history should talk to an oncologist first.
What is the SLU-PP-332 dose for humans?
There is no validated human dose, because there is no human trial. We do not publish dose numbers, schedules or cycles for it.
Is SLU-PP-332 banned in sport?
WADA bans metabolic modulators, and its 2027 list names SLU-PP-332 as an example, effective January 1, 2027, according to a law-firm briefing. Tested athletes should treat it as prohibited.
Can you take SLU-PP-332 with retatrutide?
No human study has tested the pair, and we do not cover combinations. Ask a physician about any medicine you already take.
Can you buy SLU-PP-332 on Amazon?
Amazon is not a research-chemical vendor, so a listing there cannot show a lot-specific lab report you can trace. Treat a missing lot-matched lab report as a red flag on any site.
The mice ran longer. You are not a mouse. Chase the proof, not the promise.
Next: how to verify a peptide COA, best peptide vendors and peptide scams to avoid.