List of 66 Powerful Nootropics

There are over hundreds of nootropics and more are yet to be made and discovered. Some are manufactured in labs. And some are made by nature and can be found in plants and under the sea. This nootropics list consist of 66 of them.


Adrafinil is a central nervous stimulant discovered in 1970 by a French pharmaceutical company called LafoŶ Laboratories. Originally prescribed for patients with narcolepsy. It provides mental clarity, focus, and wakefulness.


Agmatine is an endogenous neuromodulator discovered in 1910 by Albrecht Kossel. It improves insulin sensitivity, decrease blood pressure, helps with pain management, and may improve testosterone production.


An acetylated version of carnitine. Alcar is neuroprotective and can mild ADHD, enhance mitochondrial energy production and alertness. Works great with cholinergic supplements.

Alpha GPC

A natural choline substance. In Europe, it’s prescribed to treat Alzheimer’s disease. It improves memory, attention span, and learning abilities.


Aniracetam is often centered around holistic thinking and creativity. It’s one of most effective Racetam created back in 1970’s. It improves memory, learning, attention span concentration, and can also ease anxiety.


Ashwagandha is an adaptogenic herb that protects brain cells, reduce anxiety, depression, and enhance social cognition and auditory verbal working memory.

Bacopa Monnieri

A famous Ayurveda herb used for enhancing cognition, reduce anxiety and improve memory.


A widely used nootropic for alertness. Caffeine is a central nervous stimulant with some substantial evidence it can protect against neurodegenerative diseases, counting the source is organic.


Centrophenoxine is a cholinergic compound sold as an anti-aging agent that enhance intracellular water content.


Choline is required for liver protection, cell membrane structure, and neurotransmitter function. It’s the building block of acetylcholine, an important neurotransmitter for intelligence and memory.


A naturally occurring brain chemical used (in Europe) for Alzheimer’s, cerebrovascular diseases, head trauma, ADHD, glaucoma, age-related memory loss, and Parkison’s disease.


Cocoa stimulates dopamine and serotonin. It can improve brain function if taken with a nutrient packed diet.


A nootropic that belongs in the Racetam group made by Mitsubishi Tanabe Pharma Corporation to test it for Alzheimer’s. Coluracetam is a potent choline uptaker. It improves learning impairment and may enhance visual perception.


Popular nootropic for physical performance. Creatine is produced in the liver, pancreas, and kidneys. It’s stored in the muscles and used as a source of energy. Creatine has shown to improve working memory.


DHEA is manufactured in a lab and naturally by your body. It’s a hormone used for slowing down or reverse aging, and enhance thinking skills.


DMAE is found in fish such as sardines and salmons. It’s a natural substance produced in the brain that stimulates acetylcholine. Research have shown it may be useful for ADHD.


A psychoactive drug made in Italy in 1983 for treating senile dementia. It increases dopamine in some degree, improves memory, and enhances the immune system.

Fish Oil

Fish oil is brain candy. Omega-3 is crucial for pre—and postnatal brain development, both structure and function for all ages. It improves memory and overall cognitive function.


Galantamine is derived from Caucasian snowdrop. It’s a potent neuroprotective nootropic that prevents brain cells from dying. Used for treating Alzheimer’s and inducing lucid dreams.

Ginkgo Biloba

A herb that originates from maidenhair tree. Ginkgo Biloba is known for possessing detoxifying properties and being a potent antioxidant. It’s used for improving memory and in the early stage of Alzheimer’s disease.


A famous herb for thousands of years to promote overall health. Panax Ginseng is used in energy drinks and as a nootropic to improve thinking ability.


Guanfacine is approved in EU and US for treating ADHD for both children and adults. It improves working memory and regulates impulse.


Guarana originates from the rain forest and consist of  high amounts of caffeine. It’s used in energy drinks, lollipops, and chewing gums. It improves mental energy and function.


Hordenine is found in plants and it’s an ingredient in nutritional supplements. It can help with weight loss, enhance physical performance, and brain function. It re- leases norepinephrine and classifies as a CNS stimulants.

Huperzia Serrata

Huperzia Serrata contains Huperzine A (HupA). It’s an herbal extract that has inhibitory effects on acetylcholinesterase, which is an enzyme that depletes acetylcholine. Acetylcholine is critical for memory and learning, suboptimal levels are observed in Alzheimer’s patients.


Made for treating Alzheimer’s and other memory-related cognitive declines. Idebenone is a potent antioxidant made by Takeda Pharmaceutical. It may improve memory, learning, and for its antioxidant effects– it promotes brain health.


Inositol is a glucose isomer and a vitamin B member. It has calming effects and currently studied for treating Alzheimer’s, depression, and panic attacks.


A member of the pepper family used for centuries in the South Pacific as a ceremonial beverage. It’s used for anxiety, sleep, asthma, and urinary tract infection.


Chewing Kratom is similar to drinking coffee in Asia. It originates from Thailand. Kratom acts as a stimulant and it’s used for anxiety, insomnia, depression, and opioid withdrawal.


A natural occurring amino acid in the body. It might help to slow down Alzheimer’s and improve memory in elderly. It’s beneficial for those who are deficient.

Lion’s Mane

A medical mushroom with nootropic benefits. Lion’s mane stimulate nerve growth factor and improves memory, focus, and attention. It also has anti-cancer properties and acts as a strong immune modulator.


An amino acid that reduces stress, and anxiety. Stacking theanine with caffeine improves focus, attention, and alertness. It has also shown to induce alpha brain activity, which is often achieved during meditation.


An essential mineral important for more than 300 biochemical reactions in the body. Magnesium enhances learning abilities and memory. Magnesium Threonate is a potent form that also delivers mg to the brain.


A hormone that regulates sleep and it’s also a powerful antioxidant.

Melissa Officinalis

Mellissa Officinalis is a plant used for improving sleep quality, memory, alertness, support the liver, and protect brain cells.

Methylene Blue

Methylene blue has shown to improve memory consolidation and being a neuroprotective compound that acts as an anti- oxidant in the mitochondria region.


Methylphenidate is a central nervous stimulant approved by the FDA and prescribed for ADHD and narcolepsy.


Modafinil is a wakefulness-promoting drug approved by the FDA for patients with narcolepsy. It affects numerous of brain chemicals thus providing many cognitive benefits.


A nootropic within the Racetam family. Nefiracetam enhances GABAeric, cholinergic, and monomeric signaling.


Nicotine is an alkaloid that acts as an acetylcholine receptor agonist. It has mood- altering effects and can improve memory, attention and reaction time.


Similar to Piracetam but stronger and higher bioavailability. Noopept has neuroprotective properties and can improve learning and memory.


Oxiracetam is another Racetam related to Piracetam. It improves learning, logical thinking, concentration, focus, and energy levels.


Phenibut is similar to a natural occurring neurotransmitter called GABA. It will reduce anxiety, social anxiety, fear, and improve sleep quality.


Essential amino acid the body converts to Tyrosine. It’s used for depression, mood, memory, learning, and attention


Phenylpiracetam is a modified version of piracetam, a group of atoms are added to enable blood-brain penetration. It increases the body’s tolerance to cold and other forms of biological stressors.


A nutrient part of your cell membrane. It’s found in high amount in the brain. It improves memory, learning, concentration, and has shown to reduce symptoms of ADHD.


Picamilon was made in the Soviet Union in 1969 as a prodrug to GABA. It stimulates GABA and thus induces calming effects. Also used for treating insomnia.


The first nootropic ever made. Piracetam improves mitochondrial function, enhance writing and verbal fluency. It can also improve memory and learning.


A derivative from piracetam. It’s more potent and requires a less dose. It’s useful for treating senile dementia and improving memory, learning, and social fluency.


A plant-based chemical found in apples, tea, red wines, and onions. Quercetin stimulates brain mitochondrial bio-genesis.

Rhodiola Rosea

Rhodiola is an adaptogen plant native to European countries that help the body to adapt to stress. It has many uses including enhancing mental energy, memory, and the immune system.

Salvia Lavandulifolia

A small woody herbaceous perennial na- tive to Spain and France. It improves word recall and found to stimulate and inhibit the breakdown of acetylcholine.

St. John’s Wort

A yellow flower used for decades to elevate mood. Evidence has shown it can be used to treat mild depression.


Sulbutiamine is two Thiamine bound together used for protecting neuronal cells from oxygen and glucose deprivation. As a nootropic, it’s used for memory, mood, and motivation.


Strong nootropic that can prevent amnesia and it’s good for mood and memory. It’s stronger than Noopept. It’s a young nootropic that needs more study.


Taurine is an organic acid found in animal tissues (not bull urine). Important for the central nervous system and has a calming effect on the brain. It’s found in energy drinks.


Effective nootropic for depression and anxiety. May also be beneficial for ADHD. Tianeptine can also repair structural damage on the brain caused by depression.


An amino acid used to mild depression, ADHD, and improving alertness


An ampakine like drug with higher potency than Piracetam. Used to improve neuroplasticity and stimulate acetylcholine production leading to enhanced cognition and focus.


Uridine is one of four basic component of ribonucleic acid. Used for improving neuroplasticity, focus, and memory recall. Must have nootropic in a stack for brain repair.


Vinpocetine originates from the periwinkle plant and has been used for treating vascular diseases.  It improves blood flow to the brain, learning and memory.

Vitmain B1

Found in many foods including beans, nuts, and meat. It’s used for mental clarity, enhance learning, fight stress, and increase energy.

Vitamin B

A water-soluble vitamin important for brain health and function. Supplements can improve mental clarity, sleep quality, neuronal health, and concentration.

Vitamin D

A fat-soluble vitamin found in few food sources. Exposure to sunlight triggers vitamin d synthesis. An essential vitamin for brain development and overall health.

Vitamin K

A fat-soluble vitamin that plays an important role in the central and peripheral nervous system as a signaling molecule. Supplements can aid to maintain a healthy central nervous system and prevent age-related changes in the brain with its neuroprotective benefits.


Dietary supplements made from Griffonia simplicifolia. 5-HTP converts to serotonin in the brain and is used for depression,  anxiety, fibromyalgia, ADD, and insomnia.

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