5-Amino-1MQ is a small-molecule NNMT inhibitor, not a peptide. Every fat-loss and muscle result attached to it comes from mice or cell culture, and no human trial exists. If you buy it as a research chemical, the lab report for the lot in your hands is the only thing that tells you what is in the vial.
This page covers what the studies measured, what two US suppliers publish in their lab reports, and how to read a report before you order. The vials come first.
5-Amino-1MQ vials with a published lab report
Both suppliers below publish a report for this compound, name the lab, give a lot number and let you work out the price per milligram. The full comparison sits further down.
Elite Edge Biotech
$30 for 5 mg · $80 for 50 mg
- Lot report from MZ Biolabs: 99.17% HPLC purity (5 mg lot)
- Ships in 1 to 3 business days with tracking, free US shipping over $200
- Sealed items returnable within 30 days
Platinum Biolabs
$56.25 for 50 mg with the referral discount · $75 list
- Lot T-5AM-0015, Axiom Analytics: 99.84% HPLC purity, 53.42 mg found against a 50 mg label
- Sterility PCR screen and fentanyl screen: none detected
- US shipping, arrives in 1 to 2 days, 30-day returns
For laboratory research use only. Not for human or veterinary use. Prices come from the supplier product pages and can change.
What is 5-amino-1MQ?
5-Amino-1MQ (5-amino-1-methylquinolinium, PubChem CID 950107) is a small molecule of about 159 daltons that inhibits nicotinamide N-methyltransferase, or NNMT. NNMT moves a methyl group from S-adenosylmethionine (SAM) onto nicotinamide, which produces 1-methylnicotinamide and uses up nicotinamide that cells could otherwise recycle into NAD+. In cultured fat cells, 5-amino-1MQ lowered 1-methylnicotinamide and raised NAD+ and SAM.[1]
The enzyme became a drug target because NNMT activity is higher in the fat tissue of obese mice, and blood levels of 1-methylnicotinamide track body mass index and waist circumference in people.[1] That association is the human side of the story. Nobody has published a trial that gives the compound to people.
Is 5-amino-1MQ a peptide?
No. A peptide is a chain of amino acids. 5-Amino-1MQ is a quinolinium ring carrying one amine group and one methyl group, with a mass near 159 Da. Suppliers list it under peptides because they sell it beside peptides, and the label stuck. It matters when you read a lab report: the identity test for this compound looks for a mass of 159.2 Da, not a peptide sequence.
What do the 5-amino-1MQ studies actually show?
Six papers carry the story. All six are cell or animal work.
| Study | Model | What was measured |
|---|---|---|
| Neelakantan 2018[1] | Diet-induced obese male mice, 9 per group | 20 mg/kg per injection, three subcutaneous injections a day for 11 days: body weight down 5.1% against a 1.4% gain in controls, fat pad mass about 35% lower, cholesterol about 30% lower, food intake unchanged. |
| Neelakantan 2019[2] | 24-month-old mice after a muscle injury | At 10 mg/kg, peak muscle torque about 70% higher and muscle fibre area nearly doubled against controls. |
| Dimet-Wiley 2022[3] | Diet-induced obese mice on a low-fat diet | 5-Amino-1MQ plus the diet switch brought body weight and fat mass back to lean-mouse levels. The diet switch alone did not. Gut bacteria shifted too. |
| Dimet-Wiley 2024[4] | Aged mice (22 to 24 months), 7 to 10 per group | 10 mg/kg once a day for eight weeks: grip strength about 40% above sedentary controls. Intensive exercise alone gave 20%, and the two together gave 60%. |
| Akar 2021[5] | HeLa cervical cancer cells in culture | Slower cell proliferation and signs of apoptosis. No clear effect on HEK-293 cells. |
| Yang 2024[6] | Bladder cancer mouse models | The iodide salt reduced tumour growth and strengthened the effect of an anti-PD-L1 antibody. |
Read the pattern, not the headline. The first four papers come from the group that developed the compound. The last two are independent, and they test cancer biology rather than weight. The weight result rests on nine treated mice over 11 days.
Doses matter here too. A mouse dose is not a human dose, and without human pharmacokinetics nobody can scale one to the other. Any “human protocol” you read online is a guess presented as data.
Has 5-amino-1MQ been tested in humans?
No. ClinicalTrials.gov lists no study of 5-amino-1MQ or of an NNMT inhibitor, and PubMed holds no human trial of the compound. Claims about human fat loss, energy, mood or “cycles” have nothing behind them. For compounds that do have human trial data, see best peptides by goal and fat loss peptides.
5-Amino-1MQ dosage
There is no human dose, because there is no human trial. The numbers that circulate for milligrams per day, cycle length and oral versus injectable come from vendors and forums. The only published dosing is the mouse work in the table above. Distrust any page that gives a human protocol, including pages that sell the compound.
5-Amino-1MQ side effects
The 2018 mouse study reported no observable adverse effects at the doses it tested, and food intake stayed the same.[1] That is a statement about nine mice over 11 days. No human tolerability data exists, so the “common side effects” lists on vendor and forum pages are anecdote.
5-Amino-1MQ and cancer
NNMT is raised in a number of tumours. Blocking it slowed HeLa cell growth in culture[5] and tumour growth in bladder cancer mice.[6] That makes it a research direction. It is not a safety signal in either direction: nobody has studied what long-term NNMT inhibition does in a person, with or without a cancer history.
5-Amino-1MQ third-party tested: two lab reports compared
A purity number alone says little. A report earns trust when it names the lot, the lab, the method and what was measured. This is what each supplier publishes for 5-amino-1MQ.[7]
| Elite Edge Biotech | Platinum Biolabs | |
|---|---|---|
| Vial in the report | 5 mg, lot 2026-05-28 | 50 mg, lot T-5AM-0015 |
| Lab | MZ Biolabs, Tucson, AZ | Axiom Analytics, Sacramento, CA |
| Purity | 99.17%, HPLC-UV-MS method, three peaks listed | 99.84%, RP-HPLC at 214 nm, acceptance 99.25% or higher |
| Identity by mass | Method line names MS, but the report prints a UV trace and no mass reading | 159.099 Da found against 159.212 Da expected, pass within 1 Da |
| Content | Not reported | 53.42 mg found against a 50 mg label (106.8%), pass within 10% |
| Other screens | None on the report | Sterility rapid PCR: target DNA not detected. Fentanyl screen: none detected |
| Verification | Proof-of-authenticity QR code from the lab | Verify code and cryptographic seal from the lab |
| List price | $30 for 5 mg ($6.00 per mg), $80 for 50 mg ($1.60 per mg) | $75 for 50 mg ($1.50 per mg), $56.25 with the 25% referral discount ($1.13 per mg) |
| Shipping | US only, 1 to 3 business days, tracked, free over $200 | US only, arrives in 1 to 2 days |
| Returns | 30 days, sealed items | 30 days |
What the two reports do and do not tell you:
- Both pass a purity test. Purity measures how much of the signal belongs to the compound, not how much powder sits in the vial.
- Platinum’s report also measures content: 53.42 mg found against a 50 mg label. Elite Edge’s report has no content figure.
- Elite Edge’s report covers a 5 mg lot. Ask for the report that matches the size and lot you receive. Their product page says certificates go out on request.
- Platinum’s lab states that the sample was submitted by the client, so the result speaks for that vial and not for the whole lot. The same lab states that it does not itself hold ISO/IEC 17025 accreditation.
- Independent buyer-side testing shows why reports matter. Finnrick’s public 5-amino-1MQ table lists 16 tests: 6 pass, 5 fail and 5 incomplete.[8] Neither supplier appears in that table.
How to read a 5-amino-1MQ lab report
- Lot number. The lot on the report must match the lot on your vial label.
- Identity. Look for a mass result near 159.2 Da. That is the mass of the cation, so it cannot tell you which salt you have.
- Purity. Look for a named method (HPLC) and the full peak list, not a lone percentage.
- Content. Milligrams found against the label claim. Platinum’s report sets the limit at 10% either way.
- Verification. A code or QR you can check with the lab itself.
- Sample scope. Who chose the vial: the lab or the seller.
The longer version, with examples of reports that fail these checks, is in how to verify a peptide COA.
Why is 5-amino-1MQ orange?
Platinum’s lot report records the vial contents as orange. The compound is sold as a salt, and the 2024 bladder cancer paper used the iodide.[6] Colour alone proves neither purity nor salt form. The mass test reads the cation at 159 Da, so it cannot separate the iodide from the chloride. If the salt matters to your work, ask the supplier which one the lot is.
5-Amino-1MQ reviews: what user reports can and cannot tell you
Reddit threads and “amino 1 review” pages describe energy, appetite and fat loss. Those reports come from people running unknown products, unknown salts and unknown amounts, usually alongside diet and training changes, with no control group. They cannot separate the compound from the diet. With 5 of 16 independent tests failing,[8] some posters may not be taking what the label says. Use forum threads to judge how a supplier handles shipping and support. Use the lot report to judge the vial.
Where to buy 5-amino-1MQ
Searches for “5-amino-1MQ for sale” return mostly resellers with no lot report. Run the same six checks on any supplier before you order: a report for this compound, a lot number, a named lab, content in milligrams, a price per milligram and a written return policy. The wider supplier field is covered in best peptide vendors, and the failure cases are in peptide scams to avoid.
For laboratory research use only. Not for human or veterinary use.
5-Amino-1MQ FAQ
Does 5-amino-1MQ work?
In diet-induced obese mice it lowered body weight and fat mass without reducing food intake.[1] In people, nobody knows, because no trial exists.
Does 5-amino-1MQ give you energy?
There is no human data. The idea comes from the NAD+ angle: the compound raised NAD+ in cultured fat cells.[1] Energy in a person has never been measured.
Is 5-amino-1MQ better as capsules, injection or oral?
The 2018 and 2019 mouse studies used subcutaneous injection.[1][2] No study reports how a person absorbs it by any route, so capsule and oral claims rest on supplier marketing. The two suppliers on this page sell lyophilized research vials.
Can you stack 5-amino-1MQ with NAD+, MOTS-c or SLU-PP-332?
No study combines them. The only combination data is 5-amino-1MQ with a low-fat diet and with exercise in mice.[3][4] For the other compounds on their own, see NAD+, MOTS-c and SLU-PP-332.
What is the difference between 5-amino-1MQ chloride and iodide?
They are two salts of the same cation. A lab report that only shows a 159 Da mass cannot tell them apart, so ask the supplier which salt a lot contains.
How should 5-amino-1MQ vials be stored?
Follow the supplier’s sheet. Platinum lists lyophilized storage at -20°C, protected from light. Elite Edge says sealed vials stay dry and protected from light, with the 2 to 8°C or -20°C requirement printed in the shipment paperwork.
Where can I see the lab report?
Platinum links a PDF report from the product page: 5-amino-1MQ purity report. Elite Edge shows its 5 mg lot report in the product gallery and sends the report for other lots on request.
Sources
- Neelakantan H, Vance V, Wetzel MD, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochem Pharmacol. 2018;147:141-152. doi:10.1016/j.bcp.2017.11.007
- Neelakantan H, Brightwell CR, Graber TG, et al. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem Pharmacol. 2019;163:481-492. doi:10.1016/j.bcp.2019.02.008
- Dimet-Wiley A, Wu Q, Wiley JT, et al. Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice. Sci Rep. 2022;12:484. doi:10.1038/s41598-021-03670-5
- Dimet-Wiley AL, Latham CM, Brightwell CR, et al. Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice. Sci Rep. 2024;14:15554. doi:10.1038/s41598-024-66034-9
- Akar S, Duran T, Azzawri AA, et al. Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in HeLa cells. J Obstet Gynaecol. 2021;41(8):1240-1245. doi:10.1080/01443615.2020.1854696
- Yang M, Wang B, Hou W, et al. NAD metabolism enzyme NNMT in cancer-associated fibroblasts drives tumor progression and resistance to immunotherapy by modulating macrophages in urothelial bladder cancer. J Immunother Cancer. 2024;12(7). doi:10.1136/jitc-2024-009281
- Platinum Biolabs and Elite Edge Biotech product pages and published lab reports for 5-amino-1MQ (Axiom Analytics lot T-5AM-0015; MZ Biolabs lot 2026-05-28).
- Finnrick, 5-Amino-1MQ test history: finnrick.com/products/5-amino-1mq.