Phenibut HCL – A Review of Benefits, Side Effects and Dosage

Phenibut originates from a natural calming brain chemical called GABA.

It’s used to improve sleep patterns, release anxiety, and enhance brain function.

It was created in Russia in 1960 for cosmonauts to lower stress without affecting performance. Years later, the drug has shown more promising results. Studies published in scientific journals reveals neuro and cardioprotective properties. Phenibut can protect neurons during stress and oxygen deprivation. Enhance blood flow to the brain. Protect the heart muscle from chronic renal insufficiency, and lessen pressure on the ventricles.

Nowadays, it’s used as a nootropic to relieve insomnia and social anxiety.

But, Phenibut is addictive with some boring side effects. In this article, you’ll learn all about that and how to avoid them.

Improved Sexual Function & Brain Communication


Better sex and more intense orgasm – is achieved by acute stimulation of the pleasure receptors.

Phenibut can also improve (interhemispheric) right and left brain hemisphere communication.

This gives you enhanced creativity, and the ability to process information faster.

As a nootropic, Phenibut has shown some benefits for learning capacity, memory, and thinking. These benefits come from simultaneous stimulation of dopamine, and GABA-A and GABA-B receptors. But research to fully back up this area is limited. (1) (2)

What Is Phenibut Good for?

Phenibut is great to combat anxiety and improve sleep quality. Unlike other anxiolytic drugs, it has low risk to cause drowsiness. Hypnotic effects may occur with a high-dose however.

Anxiety can hinder your mental performance in different ways. Say you have an important meeting, job interview, or taking a life changing exam. The negative effects of anxiety can distort your perceptive field. Which leads to decreased productivity and decision-making.

Worst case scenario: severe anxiety takes over your mind and hijacks your ability to concentrate and finish your work.

How does Phenibut Work?

Phenibut is a potent nootropic with lasting effects. It can enter the blood-brain barrier (BBB) and perform its magic. The blood-brain barrier is like a shield protecting your brain from foreign substances. The ability to go through allows the neurotransmitter stimulation to be more effective.

When Phenibut passes through it mimics the action of GABA. The most important neurotransmitter that reduces neuronal excitability.

Stimulation fights hyperactivity and slows down neuronal impulse firing. As a result – calmer mind, body, and better decision-making skills. Creative thoughts can flow free because of less fear response from the amygdala.

Phenibut acts on GABA-A and GABA-B receptors. This is where the anxiolytic, hypnotic, sedative, and muscle relaxing effects comes from. It builds up tolerance fast. Stimulating GABA makes the brain manufacture more receptors. Those new receptors then need a higher dose to please the newcomers.


Phenibut also affects dopamine levels by making the receptor more reactive and responsive. Dopamine is an excitatory neurotransmitter important for brain function. It’s critical for the reward system. And regulates mood, focus, and personal drive.

How Does It Feel to Be on Phenibut?

phenibut dosage for euphoria

Depends on how much you take, which you’ll learn more about in the next section.

Expect relaxation and the anti-anxiety effect kick in after a few hours. You might want to go out and socialize because you’re more confident and laid back.

Sometimes euphoria – amplified emotions, usually positive – is achieved.

Music sounds more pleasurable. It’s easier to sink in and follow the instrumentals. Movies are more enjoyable as well since your brain is not firing neurons like crazy.

You’ll be in a calm, relaxed state of mind so you’re more in control of your actions.

How to Take Phenibut

Phenibut is a potent substance. How much, and when you take can result in a good or bad experience. The best lesson I’ve learned is, don’t take Phenibut daily.

Two times per week is the sweet spot. You should also take a pause now and then to prevent tolerance and withdrawal symptoms.

It doesn’t work instantly. Give it some time. The effects can be felt somewhere between 3 to 4 hours, depending on your brain chemistry and if you take it on an empty stomach.

The effective way to take Phenibut is in situations that can cause anxiety. Like a huge event where you’re exposed to hundreds of people. Or if you want to improve sleep, then you take it one hour before bed. The good thing about Phenibut is it won’t let anxiety get in your way.

You can get Phenibut in capsule or powder form. Doesn’t matter which one you choose. But if you get it in powder form, be sure to have a properly calibrated scale.

The dose depends on different factors like lifestyle, diet, and brain chemistry. There’s no perfect dose that works wonders for every individual. Phenibut requires some experimentation to find out your body’s response.

A low Phenibut dose is between 250mg-500mg. That’s the recommended starting point. Then you climb up to 1000mg (1g).

Always start low and give your body time to adapt to more GABA. Plan your day and time with Phenibut to ensure you experience the full spectrum of effects at the right moment.

How to Use Phenibut with Responsibility

phenibut side effects

When you start out it’s essential to go slow and discover your body’s tolerance. You test your body’s response from a low dose and work your way up. Take notes on how your body response to 250mg, 500mg, and up to 1g.

You’ll get a good understanding how much you should take with this method. And when you need it the most, you know how much to take.

Phenibut can stay in your body for 24 hours. When you take your first dose wait for 3 to 7 hours if you decide to take more. The dose should never extend 3000mg.

Avoid frequent Phenibut use and don’t take more than 2-3 timer peer week. Cycling it is your best choice to avoid addiction.

Phenibut Side Effects

Never mix alcohol with Phenibut or other GABA agonist.

Here’re some side effects that Phenibut can induce. Often, with a high dose and frequent use.

  • Headaches
  • Stomach discomfort
  • Nausea
  • Fatigue
  • Lightheadedness

Severe Phenibut doses can cause:

  • Unconsciousness
  • Lack of coordination
  • Memory loss
  • Hangover
  • Blurred vision
  • Nystagmus
  • Depressed respiratory drive

That’s why you start low and take notes and track your body’s Phenibut tolerance. And at the end of the day, you’ll find out what works for you.

With long-term use and high doses, Phenibut can cause withdrawal symptoms, including:

  • Negative thinking
  • Increased anxiety and stress
  • Reduced sleep quality
  • Free-floating anxiety
  • Annoyance
  • Shakiness
  • Nervousness
  • Loss of appetite

Phenibut is a potent nootropic with promising effects for anxiety, stress, and cognitive performance. With the right mindset, you don’t have to worry about withdrawal and dependence. Track your body as you try the first dose and don’t surpass 2-3g.

As the society continue to get more complex and mentally exhausting. A good strategy to put the brain to a restful sleep so it can recover will benefit you big time. I now get Phenibut from Nootropics Depot. All products are tested for purity with high standard equipment.

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