4 Most Effective Nootropics for Depression & Mood

4 Most Effective Nootropics for Depression & Mood

Are you looking for nootropics that will banish your depression and also repair the structural damage cause by it?

Then read on, because this article will teach you the best supplements you should invest in to get your mood back.

Quite frankly, not everyone take the supplements that the human brain screams for. This only cause confusion why something didn’t work.

There are effective treatments available for moderate to severe depression. Those you find here you can invest in without a prescription. First, I want to start with one of the most effective nootropic for depression, Tianeptine. Then you’ll discover the power of vitamin d, and why it is a must have. The last two nootropics are suitable if you have mild depression and need a small boost to get going.


Tianeptine is useful for major and clinical depression. It is an unscheduled drug in the US. And a prescription drug in many countries. It’s branded as Stablon, Salymbra, Coaxil, Tatinol, and Tianeurax.

Tianeptine is unique compared to typical antidepressants. Researchers have found the antidepressant effects come from stimulated glutamate receptors. This will affect neuroplasticity.

Tianeptine & Central Neuroplasticity

Mood disorders like major depression is linked to neuron dendrite shrinkage. And impairment in neuroplasticity. This is where Tianeptine gets handy. It fights the negative structural changes in the brain caused by depression. And prevents pathological changes in glutamate neurotransmission in the hippocampus and amygdala.

Scientist believes the antidepressant effects comes from the enhanced synaptic plasticity.

Tianeptine can also improve mood and relieve anxiety, a reason why people invest. Because there’s no need for individual therapy for anxiety treatment.

Unlike most antidepressant SSRIs Tianeptine lacks undesirable side effects on memory, attention, and sexual dysfunction.

Vitamin D

First of all, conquering depression starts with a healthy brain, there’s no other way around.

Vitamin d is essential for brain health and development throughout your entire life. It protects the brain against cognitive decline, elevates mood, and improve cognitive function.

Yet over a billion people worldwide are deficient…

We human have come a long way with our technology. But that has also caused few people get exposed to sunlight. And once we get outside we block the sun rays with sunscreen. Remember that tan you get in the summer? That’s how a person with a healthier brain than average looks like.

But vitamin d is much more than healthy brain and preventing depression. It’s not only a vitamin. But also a hormone that regulates the function of over 200 genes in your body.

How does it work to fight depression?

Vitamin d, in theory, works by releasing certain brain chemicals named monoamines. Monoamines are a group of “feeling good neurotransmitters” called dopamine, noradrenaline, and serotonin.

That’s how most antidepressant medications work.

There are different forms of vitamin d you can get your hands on. The one you should invest in should be Vitamin D3, or cholecalciferol from Carlson Labs.

Mucuna Pruriens

Mucuna Pruriens is a plant found in Africa and tropical Asia. The seeds are rich in L-Dopa—L-Dopa is an amino acid and a hormone that produce dopamine. It can fight depression and anxiety, but not as effective as Tianeptine and vitamin d.

Mucuna Pruriens is great for getting that small boost for mood, focus, and performance.

I take L-Dopa supplements because of the benefits it has on brain aging and health. L-Dopa can slow down the aging process in the body, too. It works by penetrating the blood-brain barrier and then convert to dopamine. Once in the brain, it fights free radicals and removes toxins from your brain and body.

It’s also a great tool to fight Parkison’s. As we age, dopamine productions drop. And thus increases the risk to develop Parkinson’s.


Sulbutiamine is part of the Vitamin B family. It’s an altered version of Thiamine. But acts like nootropics. It can cross the blood-brain barrier and increase dopamine, choline, and glutamate. These are powerful neurotransmitters with major roles for mood and personal drive.

Sulbutiamine is also prescribed in many countries for depression and anxiety. But it’s better suited for motivation, mood, mental energy—and mild depression. It’s especially relevant for motivation.

nootropics for depression


Depression affects millions of people worldwide. Nootropics can treat and help you with the symptoms and even prevent them in the future. These you find here are effective and work well.

What nootropics have you tried that has worked for you?

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