The Best Nootropics Every Brain Loves (18 Cognitive Enhancers)

What are the best nootropics you can invest in?

Nootropics works differently and produces different effects. Some are great while others aren’t worth your money.

So hereise a list of the most effective nootropics.

ALCAR 

ALCAR (Acetylcarnitine) is acetylated L-carnitine, which is produced by your body naturally. It breaks town to carnitine in the blood. Your body uses it to transport fatty acid into the mitochondria for energy.

Benefits of ALCAR:

  • Improve learning abilities, focus, and memory
  • Increase attention and alertness
  • Reduce symptoms of ADHD
  • Greatly lessen the side effects of aging
  • Burn fat

Alpha GPC

Alpha GPC is a great source of choline that can cross the blood-brain barrier and deliver choline to your brain. Choline is the precursor to acetylcholine, the neurotransmitter often associated with memory and learning. Alpha GPC also supports the structure of cellular membranes.

Benefits of Alpha GPC:

  • Improve memory and learning abilities
  • Improve attention
  • Protects against cognitive decline
  • Treat mild to moderate Alzheimer’s
  • Counteract headaches often strong nootropics can give, such as Racetams and Noopept

CBD

CBD (Cannabidiol) is an active cannabinoid found in the Cannabis. Unlike the other ingredient, THC, you can’t get high from CBD. If only 10% of what the scientist claims is true, then CBD is one of the best nootropics. But CBD doesn’t shine as a cognitive enhancer as much as a therapeutic agent.

CBD is used for:

  • Anxiety
  • Fear of public speaking
  • Cigarette addiction
  • Diabetes
  • Fibromyalgia
  • Post-traumatic stress disorder
  • Schizophrenia
  • Insomnia
  • Neuroprotection
  • Inhibit cancer cell growth
  • Stress
  • Alzheimer’s
  • Parkinson’s
  • Chronic pain

Creatine

Creatine is a nitrogenous organic acid produced in the liver. It gives energy to all the cells in your body and has an important role for brain energy homeostasis. Creatine has shown to significantly improve working memory and intelligence when processing speed is needed.

DMAE

DMAE (dimethylaminoethanol) is a choline molecule produced in the brain.  It can reduce the buildup of ”age pigment” that hurts cognitive function as we age. DMAE crosses the blood-brain barrier and enters brain cells to convert into acetylcholine, the ”learning and memory neurotransmitter.”

You can also take Centrophenoxine instead, the enhanced DMAE version with greater potency but similar effects

Benefits of DMAE:

  • Boost brainpower and creativity
  • Slow down the effects of aging
  • Improve memory
  • Improve skin tone
  • Enhanced mood and energy levels
  • Wean off some anxiety during exams
  • Induce lLucid dreams (be 100% aware you’re dreaming)
  • Increase motivation for people who are dealing with depression
  • Increase willpower

Fish/Krill Oil

 Fish oil is derived from oily fish. Oily fish has all the essential fatty acids the human brain needs. Your brain consists of at least 60% fat. This makes fish or krill oil, without a doubt, one of the best nootropics. Take 3grams each day or as it says in the bottle.

Benefits of Fish & Krill Oil:

  • Combat ADHD and Alzheimer’s
  • Improve active cognitive function (krill oil is best for this)
  • Hydrate the skin
  • Improve learning and memory
  • Keep the brain healthy throughout the years
  • Keeps the heart safe

Galantamine

Galantamine is an alkaloid synthetically derived from the bulbs and flowers of Caucasian Snowdrop and other plants. It can inhibit acetylcholinesterase, a dangerous molecule that kills acetylcholine molecules. Galantamine also binds to acetylcholine receptors and make them more sensitive. This is why it’s powerful Alzheimer’s treatment and other forms of memory problems. Healthy individuals will get impressive nootropic benefits too.

Benefits of Galantamine:

  • Induce lucid dreams
  • Improve memory abilities
  • Defends against brain trauma
  • Reduce inflammation

L-Theanine

Theanine is an amino acid found in fungal species, green tea, and some plants. It can increase alpha-waves activity in the brain within 30-45 minutes after at least 200mg. This is where the common benefits are produced. Alpha is key for selective attention processing and it’s thought to connect the subconscious mind with the conscious. Put some theanine in your coffee to enhance your experience.

Benefits of L-Theanine:

  • Improve learning and the meditation experience
  • Enhance focus
  • Promote relaxation and sleep
  • Reduce stress and the negative effects of caffeine 

LSD Micro

 LSD, or lysergic acid diethylamide, is a psychedelic drug that affects your awareness and perceptions of the surrounding. Used for spiritual reasons. And as a recreational drug. It’s not addictive but can cause anxiety, paranoia, and delusions.

Microdosing LSD can increase energy, enhance creativity, concentration, mood, and learning abilities. Music and colors are also enhanced. Anxiety is reduced greatly. LSD Micro is one of the best nootropics for personal growth.

Magnesium L-Threonate

Magnesium threonate is one of many forms of magnesium. Threonate has high bioavailability and can also deliver magnesium to your brain, unlike the other forms. This leads to improved synaptic density and plasticity.

Benefits of L-Threonate:

  • Rebuild ruptured synapses
  • Restore degraded neuronal connection for people with Alzheimer’s and other memory problems
  • Improve learning abilities and working, short, and long-term memory
  • Relieve migraine

Methylene Blue 

Methylene blue is a medication used for methemoglobinemia, a form of toxic anemia. It can cross the blood brain barrier and enhance mitochondrial function and modulate the glutamate system. As cognitive enhancer, methylene blue improves memory consolidation and fights depression. 

Noopept 

Noopept is a synthetic nootropic with a mild psychostimulatory effect. It has a similar structure to piracetam but said to be 1,000 to 5,000 stronger. Noopept can increase levels of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). These are unique proteins that handle the growth, maintenance, and survival of nerve and brain cells. Noopept also works on glutamate receptors, a powerful neurotransmitter for neural communication, learning, and memory formation.

Benefits of Noopept:

  • Reduce anxiety
  • Enhance memory and learning (primary use)
  • Enhance focus (works best if you take noopept via your nose)
  • Neuroprotective

Phenibut

Phenibut is one of the best nootropics for anxiety and insomnia. Created in Russia for astronauts. They wanted something that can reduce stress without affecting performance. An added phenyl ring enables phenibut to penetrate the blood-brain barrier. Now it’s more effective than standard GABA supplements. When Phenibut enters your brain it mimics GABA-a nad GABA-b receptors.

Phenibut is used for:

  • Depression
  • Stress
  • Anxiety
  • Insomnia
  • Alcoholism
  • Stuttering
  • Asthenia
  • Vestibular Disorders
  • Alcoholism

PRL-8-53

 PRL-8-53 is a research chemical derived from benzoic acid and phenylethylamine. Not enough studies can back up this nootropic to ensure your safety, but PRL-8-53 still has a huge interest within the nootropic community. The most talked benefit is enhanced short-term memory.The only study on humans reveals memory improvements after 5mg. Retention of verbal information was greatly improved. It might be the best nootropic to improve short-term memory.

Selank

Selank is a nootropic developed in Russia with anti-anxiety effects. It releases dopamine and serotonin to stabilize your mood and make you motivated. This is the main benefit. The effects are not sedating, but calming. Mental clarity is also enhanced. If you’re looking for a nootropic that gets you in the right mood and motivated to do your business, here it is. 

Sulbutiamine

Sulbutiamine is modified vitamin b1. It consists of two thiamine (b1) molecules that are bound together by a sulfur group. Now it’s more powerful than standard vitamin b1 because it can cross the blood-brain barrier and improve cognitive function. Sulbutiamine can improve memory, eyesight, planning skills, and erectile dysfunction. However, it was made for one reason: to reverse chronic thiamine deficiency. Thiamine is important for glucose to convert to energy in the brain.

Sunifiram

 Sunifiram is derived from piracetam but doesn’t qualify as a Racetam. It works primarily as an ampakine. Sunifiram binds to AMPA-type glutamate receptors, the critical neurotransmitter for neural activation.

Sunifiram can improve memory retention, learning abilities, and information processing. Many users report improved motivation and perception. Colors and sounds appear more vivid and more distinctive. Music sounds better, emotionally, when listening with headphones. This increased perceptual awareness can make you pay attention to details with excitement and more depth.

Tianeptine 

Tianeptine is a prescription drug for depression but also used as a nootropic. And you’ll not be surprised why. Tianeptine increases serotonin uptake in the brain, without causing negative side effects like other SSRIs. It also works on glutamate, AMPA, and NDMA receptors.

Benefits of Tianeptine:

  • Release brain-derived neurotrophic factor (BDNF)
  • Supports the survival, growth, and differentiation of neurons and synapses.
  • Inhibit structural changes and brain impairments in the hippocampus that mood disorders can cause, like depression.
  • Reduce anxiety and symptoms of depression
  • Treat erectile dysfunction
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